The Glacial Lakes and Prairie region is appropriately named after the glaciers that passed through northeast South Dakota years ago. Thanks to the glaciers, this region now boasts 120 clear blue lakes and miles of gorgeous prairie land.

Today this region features many activities and attractions including casinos in Watertown and Flandreau, the Fort Sisseton Historical Festival and Milbank Trainfest. The region is also home to 14 state parks and recreation areas, two national wildlife refuges, the Terry Redlin Art Center in Watertown, and many more outdoor activities such as fishing, hunting, and water sports.

The northeast region is home to two main healthcare systems, Sanford and Avera, with networks of strategically placed satellite clinics. In addition, there are several smaller community-based primary care group practices located throughout the northeast region.